Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: Schizophrenia linkage collaborative group III
Identifieur interne : 00C210 ( Main/Exploration ); précédent : 00C209; suivant : 00C211Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: Schizophrenia linkage collaborative group III
Auteurs : D. F. Levinson [États-Unis] ; P. Holmans [France] ; R. E. Straub [États-Unis] ; M. J. Owen [Royaume-Uni] ; D. B. Wildenauer [Allemagne] ; P. V. Gejman [États-Unis] ; A. E. Pulver [États-Unis] ; C. Laurent [France] ; K. S. Kendler [États-Unis] ; D. Walsh [États-Unis] ; N. Norton [Royaume-Uni] ; N. M. Williams [Royaume-Uni] ; S. G. Schwab [Allemagne] ; B. Lerer [Nouvelle-Zélande] ; B. J. Mowry [Australie] ; A. R. Sanders [États-Unis] ; S. E. Antonarakis [États-Unis] ; J.-L. Blouin [États-Unis] ; J.-F. Deleuze [France] ; J. Mallet [France]Source :
- American journal of human genetics [ 0002-9297 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Schizophrenia candidate regions 33-51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734 informative multiplex pedigrees (824 independent affected sibling pairs [ASPs], or 1,003 ASPs when all possible pairs are counted), which were collected in eight centers. Cases with diagnoses of schizophrenia or schizoaffective disorder (DSM-IIIR criteria) were considered affected (n = 1,937). Data were analyzed with multipoint methods, including nonparametric linkage (NPL), ASP analysis using the possible-triangle method, and logistic-regression analysis of identity-by-descent (IBD) sharing in ASPs with sample as a covariate, in a test for intersample heterogeneity and for linkage with allowance for intersample heterogeneity. The data most supportive for linkage to schizophrenia were from chromosome 6q; logistic-regression analysis of linkage allowing for intersample heterogeneity produced an empirical P value <.0002 with, or P =.0004 without, inclusion of the sample that produced the first positive report in this region; the maximum NPL score in this region was 2.47 (P =.0046 ), the maximum LOD score (MLS) from ASP analysis was 3.10 (empirical P =.0036), and there was significant evidence for intersample heterogeneity (empirical P =.0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P =.045 and with significant evidence for intersample heterogeneity (empirical P =.0096).
Affiliations:
- Allemagne, Australie, France, Nouvelle-Zélande, Royaume-Uni, États-Unis
- District de Cologne, Illinois, Maryland, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Île-de-France
- Baltimore, Bonn, Chicago, Paris, Philadelphie
Links toward previous steps (curation, corpus...)
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- to stream PascalFrancis, to step Curation: 000362
- to stream PascalFrancis, to step Checkpoint: 005C02
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Le document en format XML
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Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, Washington University</s1><s2>St. Louis</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>St. Louis</wicri:noRegion><wicri:noRegion>Washington University</wicri:noRegion><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Straub, R E" sort="Straub, R E" uniqKey="Straub R" first="R. E." last="Straub">R. E. Straub</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry and Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University</s1><s2>Richmond</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. 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V." last="Gejman">P. V. Gejman</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</s1><s2>Baltimore</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. Laurent</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératif, Centre National de la Récherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry and Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University</s1><s2>Richmond</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Health Research Board</s1><s2>Dublin</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The Health Research Board</wicri:noRegion></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N. M." last="Williams">N. M. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1><s2>Jerusalem</s2><s3>NZL</s3><sZ>14 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Psychiatry, University of Queensland and Queensland Centre for Schizophrenia Research, Wolston Park Hospital</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Antonarakis, S E" sort="Antonarakis, S E" uniqKey="Antonarakis S" first="S. E." last="Antonarakis">S. E. Antonarakis</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Genetics, University of Geneva Medical School</s1><s2>Geneva</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Blouin, J L" sort="Blouin, J L" uniqKey="Blouin J" first="J.-L." last="Blouin">J.-L. Blouin</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Genetics, University of Geneva Medical School</s1><s2>Geneva</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Aventis SA</s1><s2>Paris</s2><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératif, Centre National de la Récherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0466297</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0466297 INIST</idno><idno type="RBID">Pascal:00-0466297</idno><idno type="wicri:Area/PascalFrancis/Corpus">005E08</idno><idno type="wicri:Area/PascalFrancis/Curation">000362</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">005C02</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">005C02</idno><idno type="wicri:doubleKey">0002-9297:2000:Levinson D:multicenter:linkage:study</idno><idno type="wicri:Area/Main/Merge">00D150</idno><idno type="wicri:Area/Main/Curation">00C210</idno><idno type="wicri:Area/Main/Exploration">00C210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: Schizophrenia linkage collaborative group III</title><author><name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P." last="Holmans">P. Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, Washington University</s1><s2>St. Louis</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>St. Louis</wicri:noRegion><wicri:noRegion>Washington University</wicri:noRegion><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Straub, R E" sort="Straub, R E" uniqKey="Straub R" first="R. E." last="Straub">R. E. Straub</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry and Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University</s1><s2>Richmond</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Gejman, P V" sort="Gejman, P V" uniqKey="Gejman P" first="P. V." last="Gejman">P. V. Gejman</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</s1><s2>Baltimore</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. Laurent</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératif, Centre National de la Récherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry and Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University</s1><s2>Richmond</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Health Research Board</s1><s2>Dublin</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The Health Research Board</wicri:noRegion></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N. M." last="Williams">N. M. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1><s2>Jerusalem</s2><s3>NZL</s3><sZ>14 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Psychiatry, University of Queensland and Queensland Centre for Schizophrenia Research, Wolston Park Hospital</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Antonarakis, S E" sort="Antonarakis, S E" uniqKey="Antonarakis S" first="S. E." last="Antonarakis">S. E. Antonarakis</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Genetics, University of Geneva Medical School</s1><s2>Geneva</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Blouin, J L" sort="Blouin, J L" uniqKey="Blouin J" first="J.-L." last="Blouin">J.-L. Blouin</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Genetics, University of Geneva Medical School</s1><s2>Geneva</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Aventis SA</s1><s2>Paris</s2><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératif, Centre National de la Récherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome B5</term><term>Chromosome C10</term><term>Chromosome C6</term><term>Chromosome D13</term><term>Family study</term><term>Gene</term><term>Genetic determinism</term><term>Heterogeneity</term><term>Human</term><term>Linkage</term><term>Multicenter study</term><term>Pathogenesis</term><term>Schizophrenia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etude multicentrique</term><term>Liaison génétique</term><term>Homme</term><term>Schizophrénie</term><term>Gène</term><term>Déterminisme génétique</term><term>Pathogénie</term><term>Chromosome B5</term><term>Chromosome C6</term><term>Chromosome C10</term><term>Chromosome D13</term><term>Etude familiale</term><term>Hétérogénéité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Schizophrenia candidate regions 33-51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734 informative multiplex pedigrees (824 independent affected sibling pairs [ASPs], or 1,003 ASPs when all possible pairs are counted), which were collected in eight centers. Cases with diagnoses of schizophrenia or schizoaffective disorder (DSM-IIIR criteria) were considered affected (n = 1,937). Data were analyzed with multipoint methods, including nonparametric linkage (NPL), ASP analysis using the possible-triangle method, and logistic-regression analysis of identity-by-descent (IBD) sharing in ASPs with sample as a covariate, in a test for intersample heterogeneity and for linkage with allowance for intersample heterogeneity. The data most supportive for linkage to schizophrenia were from chromosome 6q; logistic-regression analysis of linkage allowing for intersample heterogeneity produced an empirical P value <.0002 with, or P =.0004 without, inclusion of the sample that produced the first positive report in this region; the maximum NPL score in this region was 2.47 (P =.0046 ), the maximum LOD score (MLS) from ASP analysis was 3.10 (empirical P =.0036), and there was significant evidence for intersample heterogeneity (empirical P =.0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P =.045 and with significant evidence for intersample heterogeneity (empirical P =.0096).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>District de Cologne</li><li>Illinois</li><li>Maryland</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Île-de-France</li></region><settlement><li>Baltimore</li><li>Bonn</li><li>Chicago</li><li>Paris</li><li>Philadelphie</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name></region><name sortKey="Antonarakis, S E" sort="Antonarakis, S E" uniqKey="Antonarakis S" first="S. E." last="Antonarakis">S. E. Antonarakis</name><name sortKey="Blouin, J L" sort="Blouin, J L" uniqKey="Blouin J" first="J.-L." last="Blouin">J.-L. Blouin</name><name sortKey="Gejman, P V" sort="Gejman, P V" uniqKey="Gejman P" first="P. V." last="Gejman">P. V. Gejman</name><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><name sortKey="Straub, R E" sort="Straub, R E" uniqKey="Straub R" first="R. E." last="Straub">R. E. Straub</name><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name></country><country name="France"><noRegion><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P." last="Holmans">P. Holmans</name></noRegion><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. Laurent</name><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name></noRegion><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N. M." last="Williams">N. M. Williams</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name></region><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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